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Phenotypes Associated with This Genotype
Genotype
MGI:5296959
Allelic
Composition
Aebp2Gt(BC0681)Wtsi/Aebp2+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aebp2Gt(BC0681)Wtsi mutation (0 available); any Aebp2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

White spotting on the tail and toes of Aebp2Gt(BC0681)Wtsi/Aebp2+ mice

muscle
• colonic aperistalsis

digestive/alimentary system
• enlarged, green colored colon lacking neural crest derived ganglia
• mice show a 50-70% reduction in the density of ganglion cells in the section between the anus and the cecum
• seem to have difficulty passing feces
• colonic aperistalsis

growth/size/body
• tend to have a pot shaped belly

pigmentation
• white spotting at the tail tip
• length of the spot is increased in heterozygotes produced from crosses of heterozygotes compared to crosses of heterozygotes with wild-type mice
• of the feet and tail
• about 60% of heterozygotes show white toes on the hind limbs

behavior/neurological
• about 70% of mice lack a brisk acoustic response

integument
• white spotting at the tail tip
• length of the spot is increased in heterozygotes produced from crosses of heterozygotes compared to crosses of heterozygotes with wild-type mice

limbs/digits/tail
• white spotting at the tail tip
• length of the spot is increased in heterozygotes produced from crosses of heterozygotes compared to crosses of heterozygotes with wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory