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Phenotypes Associated with This Genotype
Genotype
MGI:5296788
Allelic
Composition		 Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic
Background		 involves: BALB/c * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
Sh3kbp1tm1Kuro mutation (0 available); any Sh3kbp1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176805 )
N
• T cell independent type II antibody responses are restored
decreased B-1a cell number ( J:176805 )
• B-1a cell development continues to be defective

hematopoietic system
decreased B-1a cell number ( J:176805 )
• B-1a cell development continues to be defective

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory