Phenotypes for Cd79a Nfatc1 Nfatc2 MGI:5295256 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nfatc1^tm1Rao/Nfatc1^tm1Rao Nfatc2^tm1Rao/Nfatc2^tm1Rao Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Nfatc1^tm1Rao mutation (0 available); any Nfatc1 mutation (50 available)
Nfatc2^tm1Rao mutation (3 available); any Nfatc2 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:177319 )

• stimulated B cells exhibit reduced ability to induced T cell proliferation

decreased interleukin-2 secretion ( J:177319 )

• from stimulated B cells

hematopoietic system

abnormal B cell physiology ( J:177319 )

• stimulated B cells exhibit reduced ability to induced T cell proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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