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Phenotypes Associated with This Genotype
Genotype
MGI:5295253
Allelic
Composition		 Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal B cell calcium ion homeostasis ( J:177319 )
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells

immune system
increased B cell apoptosis ( J:177319 )
• alpha-IgM-mediated
decreased B cell proliferation ( J:177319 )
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
abnormal class switch recombination ( J:177319 )
• to IgG3 induced by T cell-independent type II antigens
decreased B cell number ( J:177319 )
• in the spleen
decreased B-1a cell number ( J:177319 )
• 5- to 10-fold in peritoneal washes
abnormal B cell calcium ion homeostasis ( J:177319 )
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
abnormal marginal zone B cell physiology ( J:177319 )
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

hematopoietic system
increased B cell apoptosis ( J:177319 )
• alpha-IgM-mediated
decreased B cell proliferation ( J:177319 )
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
abnormal class switch recombination ( J:177319 )
• to IgG3 induced by T cell-independent type II antigens
decreased B cell number ( J:177319 )
• in the spleen
decreased B-1a cell number ( J:177319 )
• 5- to 10-fold in peritoneal washes
abnormal B cell calcium ion homeostasis ( J:177319 )
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
abnormal marginal zone B cell physiology ( J:177319 )
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

cellular
increased B cell apoptosis ( J:177319 )
• alpha-IgM-mediated
decreased B cell proliferation ( J:177319 )
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory