Phenotypes Associated with This Genotype

Genotype
MGI:5293356

• Allelic Composition: Fkbp1a^tm1Slh/Fkbp1a^tm1Slh; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:176731 )

• muscles exhibit increased abnormal mitochondrial compared with wild-type muscles

abnormal muscle physiology ( J:176731 )

• extensor digitorum longus muscle-specific force and action potential-triggered calcium transient amplitudes are reduced compared to in wild-type muscles

• muscles exhibit leaky calcium channels indicated by enhanced frequency of calcium sparks compared with wild-type mice

• muscles exhibit S107-resistant oxidative stress unlike wild-type muscles

• S107-treatment does not improve abnormal muscle physiology

abnormal muscle contractility ( J:176731 )

• extensor digitorum longus muscle-specific force is reduced compared to in wild-type muscles

homeostasis/metabolism

impaired exercise endurance ( J:176731 )

• reduced

cellular

oxidative stress ( J:176731 )

• S107-resistant oxidative stress in muscles

behavior/neurological

impaired exercise endurance ( J:176731 )

• reduced