Phenotypes Associated with This Genotype

Genotype
MGI:5286604

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor^{tm1.1(rtTA,EGFP)Nagy}; Smn1^tm1Msd/Smn1⁺; Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb; Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb; Tg(tetO-SMN2,-luc)#aAhmb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174960 )

• only one mouse treated with doxycycline at P2 survived for 151 days

postnatal lethality, complete penetrance ( J:174960 )

• un-induced mice die on average at P14

• however, mice treated with doxycycline at E13 or at birth live for over 200 days

digestive/alimentary system

abnormal intestine morphology ( J:174960 )

• some doxycycline-treated mice exhibit impacted bowel and pockets of fluid and gas unlike control mice

growth/size/body

decreased body size ( J:174960 )

• doxcycline-treated mice are smaller than control mice

behavior/neurological

behavior/neurological phenotype ( J:174960 )

N • doxycycline-treated mice exhibit normal motor function

decreased locomotor activity ( J:174960 )

• in doxcycline-treated mice close to death

hearing/vestibular/ear

abnormal ear morphology ( J:174960 )

• some doxycycline-treated mice exhibit ear necrosis compared with control mice

nervous system

nervous system phenotype ( J:174960 )

N • doxycycline-treated mice exhibit normal endplates and miniature endplate currents and neuromuscular junctions