Phenotypes Associated with This Genotype

Genotype
MGI:5285914

• Allelic Composition: Opn4^{tm1.1(cre)Saha}/Opn4⁺; Pou4f2^tm4(DTA)Whk/Pou4f2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:174940 )

N • mutants are able to photoentrain (their circadian phase) like controls; also, activity

impaired pupillary reflex ( J:174940 )

• the papillary light reflex (PLR) is significantly attenuated at high and low light intensities in the middle of the day (zeitgerber time 8, ZT8); in the middle of the night (ZT20), mice show no PLR

abnormal circadian behavior period ( J:174940 )

• animals show a minor deficit in period lengthening under constant light conditions

nervous system

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas

vision/eye

vision/eye phenotype ( J:174940 )

N • visual acuity is comparable to wild-type animals

impaired pupillary reflex ( J:174940 )

• the papillary light reflex (PLR) is significantly attenuated at high and low light intensities in the middle of the day (zeitgerber time 8, ZT8); in the middle of the night (ZT20), mice show no PLR

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas