Phenotypes Associated with This Genotype

Genotype
MGI:5285913

• Allelic Composition: Opn4^{tm1.1(cre)Saha}/Opn4⁺; Pou4f2^tm4(DTA)Whk/Pou4f2⁺; Tg(CAG-Bgeo/ALPP)1Lbe/0
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olivary pretectal nucleus morphology ( J:174940 )

• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls

abnormal innervation ( J:174940 )

• innervation of the intergeniculate leaflet (IGL) is markedly reduced

decreased retina ganglion cell number ( J:174940 )

• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ Opn4^{tm1.1(cre)Saha/+} animals

vision/eye

decreased retina ganglion cell number ( J:174940 )

• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ Opn4^{tm1.1(cre)Saha/+} animals