Phenotypes for Htra1 Tg(BEST1-HTRA1)#Ybf MGI:5285553 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Htra1^tm1Ybf/Htra1^tm1Ybf Tg(BEST1-HTRA1)#Ybf/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htra1^tm1Ybf mutation (0 available); any Htra1 mutation (53 available)
Tg(BEST1-HTRA1)#Ybf mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Similar development of polypoidal choroidal vasculopathy in Htra1^tm1Ybf/Htra1^tm1Ybf Tg(BEST1-HTRA1)#Ybf/0 mice as in Tg(BEST1-HTRA1)#Ybf/0 mice

vision/eye

abnormal optic choroid morphology ( J:175227 )

• defects resembling polypoidal choroidal vasculopathy (PCV) are seen

cardiovascular system

aneurysm ( J:175227 )

• small hyperfluorescent dots consistent with microaneurysmal dilations are seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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