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Phenotypes Associated with This Genotype
Genotype
MGI:5141759
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Sos1tm1.1Les/Sos1tm1.1Les
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Sos1tm1.1Les mutation (0 available); any Sos1 mutation (69 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:174536 )
• marked reduction in both proliferation and differentiation into DP cells on a per cell basis
abnormal T cell differentiation ( J:174536 )
• marked reduction in both proliferation and differentiation into DP cells on a per cell basis

hematopoietic system
decreased T cell proliferation ( J:174536 )
• marked reduction in both proliferation and differentiation into DP cells on a per cell basis
abnormal T cell differentiation ( J:174536 )
• marked reduction in both proliferation and differentiation into DP cells on a per cell basis

cellular
decreased T cell proliferation ( J:174536 )
• marked reduction in both proliferation and differentiation into DP cells on a per cell basis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory