Phenotypes Associated with This Genotype

Genotype
MGI:5086106

• Allelic Composition: Gt(ROSA)26Sor^tm2Bet/Gt(ROSA)26Sor^tm2Bet; Speer6-ps1^{Tg(Alb-cre)21Mgn}/?
• Genetic Background: involves: BALB/c * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte proliferation ( J:174261 )

• hepatocyte numbers are extremely low at 4 days of age however

abnormal bile duct morphology ( J:174261 )

abnormal bile duct development ( J:174261 )

• ductal plate cells persist to 90 days unlike controls where they are lost by 2 weeks of age

abnormal liver morphology ( J:174261 )

abnormal intrahepatic bile duct morphology ( J:174261 )

• biliary epithelial cells form ectopic tubular structures in lobules at 4 days of age

• some ectopic structures have lumina while others are disorganized

• most ectopic structures are lost by 10 days of age

• increased number of bile ducts relative to controls at 90 days of age

increased liver weight ( J:174261 )

decreased hepatocyte number ( J:174261 )

• numbers are extremely low at 4 days of age

endocrine/exocrine glands

abnormal bile duct morphology ( J:174261 )

abnormal bile duct development ( J:174261 )

• ductal plate cells persist to 90 days unlike controls where they are lost by 2 weeks of age

abnormal intrahepatic bile duct morphology ( J:174261 )

• biliary epithelial cells form ectopic tubular structures in lobules at 4 days of age

• some ectopic structures have lumina while others are disorganized

• most ectopic structures are lost by 10 days of age

• increased number of bile ducts relative to controls at 90 days of age

cellular

increased hepatocyte proliferation ( J:174261 )

• hepatocyte numbers are extremely low at 4 days of age however

growth/size/body

increased liver weight ( J:174261 )