Gt(ROSA)26Sor^tm2Bet
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm2Bet
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Bernhard Bettler
• MGI ID: MGI:5085997
• Synonyms: N2ICD
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm2Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: RBCE was used to insert an FRT flanked CAG followed by a floxed transcriptional stop site, a 5xMyc tagged Notch2 intracellular domain cDNA and a neomycin selection cassette into the targeting site of Gt(ROSA)26Sor ES cells. (J:174261)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:174261 Tchorz JS, et al., Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology. 2009 Sep;50(3):871-9
• All: 6 reference(s)