Phenotypes Associated with This Genotype

Genotype
MGI:5049917

• Allelic Composition: Alpl^tm1Jlm/Alpl^tm1Jlm; Phospho1^m1Jlm/Phospho1^m1Jlm
• Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:173678 )

• while normal numbers of mice are present at E16.5, only one stillborn mouse is observed from multiple matings

skeleton

abnormal bone mineralization ( J:173678 )

• at E16.5, mice exhibit a complete lack of skeletal mineralization of bone and cartilage compared with wild-type mice

• at E16.5, calcification of vertebral bones and femur is reduced compared to in wild-type mice

• the one stillborn mouse produced lacked mineralization in the appendicular skeleton and exhibit partial mineralization of the axial skeleton and craniofacial bones compared with wild-type mice