Phenotypes for Alpl Phospho1 MGI:5049916 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Alpl^tm1Jlm/Alpl⁺ Phospho1^m1Jlm/Phospho1^m1Jlm
Genetic Background	involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^tm1Jlm mutation (0 available); any Alpl mutation (351 available)
Phospho1^m1Jlm mutation (0 available); any Phospho1 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:173678 )

• fewer than expected mice are born

skeleton

bowed tibia ( J:173678 )

• at the site of fractures

scoliosis ( J:173678 )

• prominent at P10

decreased bone mineralization ( J:173678 )

• mice exhibit reduced bone mineralization compared with Phospho1^m1Jlm homozygotes

• mice exhibit osteoidosis unlike wild-type mice

decreased bone ossification ( J:173678 )

• secondary ossification centers are smaller and less developed than in Phospho1^m1Jlm homozygotes

fragile skeleton ( J:173678 )

• prominent at P10

limbs/digits/tail

bowed tibia ( J:173678 )

• at the site of fractures

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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