Phenotypes Associated with This Genotype

Genotype
MGI:5014819

• Allelic Composition: Slc25a37^tm1.1Kapl/Slc25a37^tm1.2Kapl; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:173284 )

• increased in the spleen in mice treated with poly (I:C)

abnormal erythropoiesis ( J:173284 )

• ineffective erythropoiesis in bone marrow and spleen in mice treated with poly (I:C)

anemia ( J:173284 )

• development of anemia in mice treated with poly (I:C)

increased erythroid progenitor cell number ( J:173284 )

• 5 fold increase in splenic erythroid progenitor cells in mice treated with poly (I:C)

• 10 fold increase in primitive erythroid progenitor cells in bone marrow

• increased number of non-viable cells in both spleen and bone marrow

increased erythroblast number ( J:173284 )

• 2 fold increase in bone marrow in mice treated with poly (I:C)

decreased erythrocyte cell number ( J:173284 )

• decreased red blood cell number in mice treated with poly (I:C)

• 50% decrease in mature red blood cell numbers in bone marrow

decreased hematocrit ( J:173284 )

• in mice treated with poly (I:C)

decreased hemoglobin content ( J:173284 )

• in mice treated with poly (I:C)

decreased mean corpuscular volume ( J:173284 )

• in mice treated with poly (I:C)

abnormal lymphocyte morphology ( J:173284 )

abnormal B cell morphology ( J:173284 )

• 6 fold decrease in cell number in mice treated with poly (I:C)

• four fold decrease in B cell lineage cells in bone marrow

abnormal T cell morphology ( J:173284 )

• 4 fold decrease in cell number mice treated with poly (I:C)

abnormal spleen morphology ( J:173284 )

• changes in spleen architecture in mice treated with poly (I:C)

enlarged spleen ( J:173284 )

• in mice treated with poly (I:C)

immune system

abnormal lymphocyte morphology ( J:173284 )

abnormal B cell morphology ( J:173284 )

• 6 fold decrease in cell number in mice treated with poly (I:C)

• four fold decrease in B cell lineage cells in bone marrow

abnormal T cell morphology ( J:173284 )

• 4 fold decrease in cell number mice treated with poly (I:C)

abnormal spleen morphology ( J:173284 )

• changes in spleen architecture in mice treated with poly (I:C)

enlarged spleen ( J:173284 )

• in mice treated with poly (I:C)

growth/size/body

enlarged spleen ( J:173284 )

• in mice treated with poly (I:C)