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Phenotypes Associated with This Genotype
Genotype
MGI:5014310
Allelic
Composition
Tg(Upk2-TAg)#Rkl/0
Genetic
Background
involves: C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype

Urothelial carcinoma in situ in Tg(Upk2-TAg)#Rkl/0 mice

neoplasm
• tumors develop prominent vasculature
• tumors exhibit hypoxia
• however, pericyte coverage is normal
• one mouse exhibited lamina propria invasion
• all mice develop bladder urothelial carcinoma in situ
• male mice develop higher bladder weight due to higher tumor burden compared with female mice
• a flat growth with large and pleomorphic nuclei and frequent mitoses

renal/urinary system
• all mice develop bladder urothelial carcinoma in situ
• male mice develop higher bladder weight due to higher tumor burden compared with female mice
• a flat growth with large and pleomorphic nuclei and frequent mitoses
• male mice develop higher bladder weight due to higher tumor burden compared with female mice

homeostasis/metabolism
• tumors exhibit hypoxia

cardiovascular system
• tumors develop prominent vasculature
• tumors exhibit hypoxia
• however, pericyte coverage is normal

Mouse Models of Human Disease
OMIM ID Ref(s)
Bladder Cancer 109800 J:173505


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory