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Phenotypes Associated with This Genotype
Genotype
MGI:5014310
Allelic
Composition
Tg(Upk2-TAg)#Rkl/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Urothelial carcinoma in situ in Tg(Upk2-TAg)#Rkl/0 mice

tumorigenesis
• tumors develop prominent vasculature (J:173505)
• tumors exhibit hypoxia (J:173505)
• however, pericyte coverage is normal (J:173505)
• tumors develop prominent vasculature (J:173505)
• tumors exhibit hypoxia (J:173505)
• however, pericyte coverage is normal (J:173505)
• one mouse exhibited lamina propria invasion (J:173505)
• one mouse exhibited lamina propria invasion (J:173505)
• all mice develop bladder urothelial carcinoma in situ (J:173505)
• male mice develop higher bladder weight due to higher tumor burden compared with female mice (J:173505)
• all mice develop bladder urothelial carcinoma in situ (J:173505)
• male mice develop higher bladder weight due to higher tumor burden compared with female mice (J:173505)
• a flat growth with large and pleomorphic nuclei and frequent mitoses (J:173505)
• a flat growth with large and pleomorphic nuclei and frequent mitoses (J:173505)

renal/urinary system
• male mice develop higher bladder weight due to higher tumor burden compared with female mice (J:173505)
• male mice develop higher bladder weight due to higher tumor burden compared with female mice (J:173505)

homeostasis/metabolism
• tumors exhibit hypoxia (J:173505)
• tumors exhibit hypoxia (J:173505)

cardiovascular system
• tumors develop prominent vasculature (J:173505)
• tumors exhibit hypoxia (J:173505)
• however, pericyte coverage is normal (J:173505)
• tumors develop prominent vasculature (J:173505)
• tumors exhibit hypoxia (J:173505)
• however, pericyte coverage is normal (J:173505)

Mouse Models of Human Disease
OMIM ID Ref(s)
Bladder Cancer 109800 J:173505


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory