Mouse Genome Informatics
tg
    Tg(Upk2-TAg)#Rkl/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Urothelial carcinoma in situ in Tg(Upk2-TAg)#Rkl/0 mice

tumorigenesis
• tumors develop prominent vasculature
• tumors exhibit hypoxia
• however, pericyte coverage is normal
• one mouse exhibited lamina propria invasion
• all mice develop bladder urothelial carcinoma in situ
• male mice develop higher bladder weight due to higher tumor burden compared with female mice
• a flat growth with large and pleomorphic nuclei and frequent mitoses

renal/urinary system
• male mice develop higher bladder weight due to higher tumor burden compared with female mice

homeostasis/metabolism
• tumors exhibit hypoxia

cardiovascular system
• tumors develop prominent vasculature
• tumors exhibit hypoxia
• however, pericyte coverage is normal

Mouse Models of Human Disease
OMIM IDRef(s)
Bladder Cancer 109800 J:173505