Phenotypes Associated with This Genotype

Genotype
MGI:5013917

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:164210 )

• all mutants develop pancreatic ductal adenocarcinoma by 3 weeks of age

increased pancreatic intraepithelial neoplasia incidence ( J:164210 )

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:164210 )

• mutants show severe exocrine pancreatic atrophy and edema along with the presence of mPanINs, metaplasias, and ducto-insular complexes and pancreatic ductal adenocarcinoma at P17

exocrine pancreas atrophy ( J:164210 )

• severe

pancreatic acinar-to-ductal metaplasia ( J:164210 )

• mutants exhibit acinar-to-ductal metaplasia

increased pancreatic ductal adenocarcinoma incidence ( J:164210 )

• all mutants develop pancreatic ductal adenocarcinoma by 3 weeks of age

increased pancreatic intraepithelial neoplasia incidence ( J:164210 )

homeostasis/metabolism

edema ( J:164210 )

• pancreas at P1-P17 shows edema

mortality/aging

postnatal lethality, complete penetrance ( J:164210 )

• mutants are moribound by weaning, with a median survival of about 17 days

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:164210 )

• mutants show severe exocrine pancreatic atrophy and edema along with the presence of mPanINs, metaplasias, and ducto-insular complexes and pancreatic ductal adenocarcinoma at P17

exocrine pancreas atrophy ( J:164210 )

• severe

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:164210