Mouse Genome Informatics
cn
    Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0

involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• in the parotid and submandibular glands between 8 and 12 months
• between 8 and 12 months
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla

digestive/alimentary system
• after pilocarpine stimulation
• in the parotid and submandibular glands between 8 and 12 months
• between 8 and 12 months

endocrine/exocrine glands
• after pilocarpine stimulation
• in the parotid and submandibular glands between 8 and 12 months
• between 8 and 12 months

hematopoietic system
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla

homeostasis/metabolism
• after pilocarpine stimulation

Mouse Models of Human Disease
OMIM IDRef(s)
Sjogren Syndrome 270150 J:172701