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Phenotypes Associated with This Genotype
Genotype
MGI:5009805
Allelic
Composition
Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id3tm2.1Zhu mutation (1 available); any Id3 mutation (5 available)
Tg(Lck-cre)#Zhu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice (J:172701)
• however, single positive cells are able to enter the medulla (J:172701)
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice (J:172701)
• however, single positive cells are able to enter the medulla (J:172701)
• slightly and unchanged by age (J:172701)
• slightly and unchanged by age (J:172701)
• slightly and unchanged by age (J:172701)
• slightly and unchanged by age (J:172701)
• in the thymus (J:172701)
• in the thymus (J:172701)
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice (J:172701)
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)

digestive/alimentary system
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• after pilocarpine stimulation (J:172701)
• after pilocarpine stimulation (J:172701)

endocrine/exocrine glands
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• between 8 and 12 months (J:172701)
• after pilocarpine stimulation (J:172701)
• after pilocarpine stimulation (J:172701)

hematopoietic system
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice (J:172701)
• however, single positive cells are able to enter the medulla (J:172701)
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice (J:172701)
• however, single positive cells are able to enter the medulla (J:172701)
• slightly and unchanged by age (J:172701)
• slightly and unchanged by age (J:172701)
• slightly and unchanged by age (J:172701)
• slightly and unchanged by age (J:172701)
• in the thymus (J:172701)
• in the thymus (J:172701)
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice (J:172701)
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)
• in the thymus (J:172701)
• in the spleen of young mice (J:172701)
• however, numbers are normal in aged mice (J:172701)

homeostasis/metabolism
• after pilocarpine stimulation (J:172701)
• after pilocarpine stimulation (J:172701)

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:172701


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory