About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5009805
Allelic
Composition
Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id3tm2.1Zhu mutation (1 available); any Id3 mutation (8 available)
Tg(Lck-cre)#Zhu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• between 8 and 12 months
• between 8 and 12 months
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice

digestive/alimentary system
• between 8 and 12 months
• between 8 and 12 months
• after pilocarpine stimulation

endocrine/exocrine glands
• between 8 and 12 months
• between 8 and 12 months
• after pilocarpine stimulation

hematopoietic system
• as detected by marker expression, T cell development from the double positive to single positive stage is delayed compared to in wild-type mice
• however, single positive cells are able to enter the medulla
• the number of mature alpha-beta T cells in the thymus is decreased compared to in wild-type mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice
• in the thymus
• in the spleen of young mice
• however, numbers are normal in aged mice

homeostasis/metabolism
• after pilocarpine stimulation

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:172701


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory