Analysis Tools
growth/size/body
weight loss
(
J:172422
)
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• aged mutants become leaner by 10.7% for males and 14.9% for females, with a significant decrease of their body weights at 1 year of age
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• lobular architecture of the liver is distorted by the development of hyperplastic hepatocyte plates
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homeostasis/metabolism
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• serum levels of alanine aminotransferase are higher than in controls
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• serum levels of aspartate aminotransferase are higher than in controls
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• injection of a single dose of diethylnitrosamine (DEN) on P15 results in an increase in the number and size of (hepatocellular carcinoma) liver tumors in mutants compared to controls
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immune system
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• intraperitoneal LPS injection elicits a stronger liver damage response in mutants than in controls as indicated by higher serum alanine aminotransferase levels
• mutants show a 130% increase in spleen size 14 days after LPS challenge as compared to 98% increase in controls indicating increased systemic inflammatory response
• mutants show increased inflammatory cell infiltration into hepatic parenchyma after LPS challenge
• circulating IL-6 and TNFalpha levels are increased following LPS injection
• LPS stimulation of isolated hepatocytes results in increased IL-6 secretion by mutant hepatocytes compared to controls
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• 93% of mutant livers contain areas with infiltrate of inflammatory cells, concentrating around the portal triads with extension into the parenchyma
• necrotic zones of livers are always associated with inflammatory cells, whereas inflammation is occasionally observed without necrosis
• 8 of 19 aged mutants develop focal microgranuloma consisting of mononuclear inflammatory cells
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liver/biliary system
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• 93% of mutant livers contain areas with infiltrate of inflammatory cells, concentrating around the portal triads with extension into the parenchyma
• necrotic zones of livers are always associated with inflammatory cells, whereas inflammation is occasionally observed without necrosis
• 8 of 19 aged mutants develop focal microgranuloma consisting of mononuclear inflammatory cells
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• one or several foci of pallor are noticeable on the liver surface of 34% of analyzed mutants
• beginning at 5 months of age, regenerative foci are noticeable in the liver and nodular regenerative hyperplasia is seen from 8 months of age
• hepatic inflammation and necrosis, leading to nodular regenerative hyperplasia
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• liver shows small focal areas as well as large areas of parenchymal necrosis, with necrosis observed in 47% of mutants
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• liver shows small focal areas of parenchymal necrosis
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• lobular architecture of the liver is distorted by the development of hyperplastic hepatocyte plates
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• hepatic parenchyma shows regenerative hyperplasia, with 13 of 19 livers having nodule formation
• the space between hepatocytes is reduced inside the nodules
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• massive hepatocyte degeneration is seen inside of or surrounding the hyperplastic nodules, in association with vacuoles containing eosinophilic material, but not in the liver parenchyma
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• fibrosis is seen at the portal triads but not near the necrosis or into the parenchyma
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• from 12-18 months of age, one or a few hepatocellular adenomas are frequently seen in mutants; tumors bulge from the liver surface, are often paler than the hepatic parenchyma, but sometimes darker or red when accompanied by bleeding
• tumors are unencapsulated, well delimited and show expanding masses of hepatocytes
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neoplasm
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• injection of a single dose of diethylnitrosamine (DEN) on P15 results in an increase in the number and size of (hepatocellular carcinoma) liver tumors in mutants compared to controls
|
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• from 12-18 months of age, one or a few hepatocellular adenomas are frequently seen in mutants; tumors bulge from the liver surface, are often paler than the hepatic parenchyma, but sometimes darker or red when accompanied by bleeding
• tumors are unencapsulated, well delimited and show expanding masses of hepatocytes
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cellular
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• liver shows small focal areas as well as large areas of parenchymal necrosis, with necrosis observed in 47% of mutants
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• liver shows small focal areas of parenchymal necrosis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular adenoma | DOID:0050868 | J:172422 | ||
