Phenotypes for Notch1 Notch2 Notch3 Tg(Mx1-cre)1Cgn MGI:5009039 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm2Rko mutation (3 available); any Notch1 mutation (116 available)
Notch2^tm1Rko mutation (0 available); any Notch2 mutation (97 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (96 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:172442 )

• increase in the granulocyte/monocyte progenitors cell population

extramedullary hematopoiesis ( J:172442 )

increased hematopoietic cell number ( J:172442 )

• increase in the granulocyte/monocyte progenitors cell population

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

neoplasm

increased leukemia incidence ( J:172442 )

• similarity to chronic myelomonocytic leukemia

immune system

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

growth/size/body

enlarged spleen ( J:172442 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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