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Phenotypes Associated with This Genotype
Genotype
MGI:5009039
Allelic
Composition		 Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm2Rko mutation (3 available); any Notch1 mutation (115 available)
Notch2tm1Rko mutation (0 available); any Notch2 mutation (97 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (93 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:172442 )
• increase in the granulocyte/monocyte progenitors cell population
increased hematopoietic cell number ( J:172442 )
• increase in the granulocyte/monocyte progenitors cell population
abnormal spleen morphology ( J:172442 )
• massive invasion of myeloid cells

neoplasm
increased leukemia incidence ( J:172442 )
• similarity to chronic myelomonocytic leukemia

immune system
abnormal spleen morphology ( J:172442 )
• massive invasion of myeloid cells

growth/size/body
enlarged spleen ( J:172442 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory