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Phenotypes Associated with This Genotype
Genotype
MGI:5007818
Allelic
Composition		 Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (93 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:171887 )
N
• increased susceptibility to ischemic injury seen in Notch3 null mice is rescued by expression of the human NOTCH3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory