Phenotypes Associated with This Genotype

Genotype
MGI:5007630

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thrombocytosis ( J:165893 )

• mutants injected with poly(I:C) to induce cre expression, exhibit 25% more platelets in the blood than controls

abnormal platelet activation ( J:165893 )

• collagen-induced platelet activation is enhanced in mutants injected with poly(I:C) to induce cre expression

increased platelet aggregation ( J:165893 )

• platelets of mutants injected with poly(I:C) to induce cre expression are induced to aggregate by a much lower level of collagen than is required to induce the same response by wild-type platelets

homeostasis/metabolism

abnormal platelet activation ( J:165893 )

• collagen-induced platelet activation is enhanced in mutants injected with poly(I:C) to induce cre expression

increased platelet aggregation ( J:165893 )

• platelets of mutants injected with poly(I:C) to induce cre expression are induced to aggregate by a much lower level of collagen than is required to induce the same response by wild-type platelets

decreased bleeding time ( J:165893 )

• mutants injected with poly(I:C) to induce cre expression have an average bleeding time that is shorter than in controls