nervous system
• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain
|
• around E11.5 multiple nodules are detected protruding from the apical surface of the mesencephalon and this phenotype becomes more severe by E12.5
• the cellular organization in the ventricular zone of the mesencephalon becomes highly irregular by E12.5
• after E12.5 dysplasia is seen in all embryos and by E13.5 dysplasia expands throughout the mesencephalon
• expansion of neural progenitor cells in the developing mesencephalon
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• protrusions consisting of neuronal mass originating from the midbrain are exposed dorsally and push into the forebrain ventrally
• expression analysis indicates disruption of adherens junctions at the ventricular surface at E12.5
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• enlarged at E13.5
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exencephaly
(
J:172044
)
• display exencephaly-like protrusions at E15.5
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• expansion of neural progenitor cells in the developing mesencephalon
|
cellular
• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain
|