Phenotypes Associated with This Genotype

Genotype
MGI:5004900

• Allelic Composition: Npm1^tm1Gsva/Npm1⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:172071 )

• due to acute myeloid leukemia, survival of pIpC-treated mice is 617 days compared with 769 days for wild-type mice

hematopoietic system

enlarged spleen ( J:172071 )

• in pIpC-treated mice

increased spleen weight ( J:172071 )

• in pIpC-treated mice

abnormal common myeloid progenitor cell morphology ( J:172071 )

• with serial replating, cells from pIpC-treated mice exhibit increased myeloid progenitor colony formation on methylcellulose compared with cells from wild-type mice

increased mean corpuscular volume ( J:172071 )

• in pIpC-treated mice

increased mean platelet volume ( J:172071 )

• in pIpC-treated mice

decreased B cell number ( J:172071 )

• pIpC-treated mice exhibit a decrease in late B cells (B220+ CD19+) compared with wild-type mice

increased leukocyte cell number ( J:172071 )

• in pIpC-treated mice

increased granulocyte number ( J:172071 )

• in pIpC-treated mice

neoplasm

increased acute promyelocytic leukemia incidence ( J:172071 )

• acute myeloid leukemia with maturation in pIpC-treated mice

increased B cell derived lymphoma incidence ( J:172071 )

• in 6 of 13 pIpC-treated mice

liver/biliary system

enlarged liver ( J:172071 )

• in pIpC-treated mice

increased liver weight ( J:172071 )

• in pIpC-treated mice

immune system

enlarged spleen ( J:172071 )

• in pIpC-treated mice

increased spleen weight ( J:172071 )

• in pIpC-treated mice

decreased B cell number ( J:172071 )

• pIpC-treated mice exhibit a decrease in late B cells (B220+ CD19+) compared with wild-type mice

increased leukocyte cell number ( J:172071 )

• in pIpC-treated mice

increased granulocyte number ( J:172071 )

• in pIpC-treated mice

growth/size/body

enlarged liver ( J:172071 )

• in pIpC-treated mice

increased liver weight ( J:172071 )

• in pIpC-treated mice

enlarged spleen ( J:172071 )

• in pIpC-treated mice

increased spleen weight ( J:172071 )

• in pIpC-treated mice