Phenotypes Associated with This Genotype

Genotype
MGI:4948089

• Allelic Composition: \Trim28^tm1.1Ipc/\Trim28^tm1.1Ipc; \Plekha5^{Tg(AMH-cre)1Flor}/\Plekha5⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:170392 )

♂N • no defects are detected in Sertoli cell or spermatogonia proliferation at P5

abnormal spermatid morphology ( J:170392 )

♂ • spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle

decreased elongated spermatid number ( J:170392 )

♂ • decrease in the number of mature spermatids

decreased male germ cell number ( J:170392 )

♂ • germ cell depletion

oligozoospermia ( J:170392 )

♂ • the caudal epididymis contains few spermatozoa

decreased testis weight ( J:170392 )

♂ • at 7 weeks and 12 months of age

testis degeneration ( J:170392 )

♂ • testicular degeneration

abnormal spermiation ( J:170392 )

♂ • mature spermatids are retained within the seminiferous epithelium

decreased litter size ( J:170392 )

♂ • sire smaller litters when crossed to wild-type females

reduced male fertility ( J:170392 )

♂ • sire fewer and smaller litters when crossed to wild-type females

endocrine/exocrine glands

decreased testis weight ( J:170392 )

♂ • at 7 weeks and 12 months of age

testis degeneration ( J:170392 )

♂ • testicular degeneration

cellular

abnormal spermatid morphology ( J:170392 )

♂ • spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle

decreased male germ cell number ( J:170392 )

♂ • germ cell depletion

oligozoospermia ( J:170392 )

♂ • the caudal epididymis contains few spermatozoa

decreased elongated spermatid number ( J:170392 )

♂ • decrease in the number of mature spermatids