Phenotypes for Cd40lg Fas Tcra MGI:4947944 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (12 available)
Fas^lpr mutation (39 available); any Fas mutation (83 available)
Tcra^tm1Mjo mutation (7 available); any Tcra mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

• decrease in the anti-snRNP and anti-Ig titers relative to mutant mice compared to mutant mice wild-type for Cd40lg

increased anti-double stranded DNA antibody level ( J:38492 )

• relative to mutant mice wild-type for Tcra

integument

integument phenotype ( J:38492 )

N	• do not develop the skin lesions seen in mutant mice wild-type for Tcra and/or Cd40lg

renal/urinary system

abnormal kidney morphology ( J:38492 )

• renal disease is decreased compared to mutant mice wild-type Cd40lg but more diseased than mutant mice wild-type for Tcra

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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