Phenotypes for Agtr1a Ldlr Tg(Tek-cre)12Flv MGI:4946112 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Agtr1a^tm1Uky/Agtr1a^tm1Uky Ldlr^tm1Her/Ldlr^tm1Her Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1a^tm1Uky mutation (1 available); any Agtr1a mutation (40 available)
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (76 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal aorta elastic fiber morphology ( J:170230 )

• angiotensin II-treated mice fed a high-fat diet exhibit decreased elastin breaks compared with similarly treated Ldlr^tm1Her homozygotes

decreased aorta wall thickness ( J:170230 )

• angiotensin II-treated mice fed a high-fat diet exhibit decreased medial thickness compared with similarly treated Ldlr^tm1Her homozygotes

abnormal ascending aorta morphology ( J:170230 )

• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta lengthening compared with similarly treated Ldlr^tm1Her homozygotes

decreased susceptibility to induced aneurysm formation ( J:170230 )

• angiotensin II-treated mice fed a high-fat diet exhibit less ascending aorta ulcers compared with similarly treated Ldlr^tm1Her homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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