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Phenotypes Associated with This Genotype
Genotype
MGI:4944270
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (17 available); any Pten mutation (87 available)
Rps6kb1tm1Gtho mutation (1 available); any Rps6kb1 mutation (55 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice injected with pIpC to induce Pten deletion have an enlarged thymus
• mice injected with pIpC to induce Pten deletion have an enlarged spleen

neoplasm
• mice injected with pIpC to induce Pten deletion, develop myeloproliferative disease and T-cell acute lymphoblastic leukemia, but at a slower rate than in single Pten mutants

mortality/aging
• mean survival time of mice injected with pIpC to induce Pten deletion is 46 days

immune system
• mice injected with pIpC to induce Pten deletion have an enlarged thymus
• mice injected with pIpC to induce Pten deletion have an enlarged spleen

endocrine/exocrine glands
• mice injected with pIpC to induce Pten deletion have an enlarged thymus

growth/size/body
• mice injected with pIpC to induce Pten deletion have an enlarged spleen


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory