Phenotypes Associated with This Genotype

Genotype
MGI:4944221

• Allelic Composition: Fas^lpr/Fas^lpr
• Genetic Background: involves: 129P2/OlaHsd * MRL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:26250 )

• about 10% of mice are moribund by 16 weeks of age

immune system

increased double-negative T cell number ( J:26250 )

• develop massive lymphadenopathy due to alpha beta DN T cell accumulation

increased gamma-delta T cell number ( J:26250 )

enlarged lymph nodes ( J:26250 )

• develop massive lymphadenopathy due to alpha beta DN T cell accumulation

kidney inflammation ( J:45448 )

• periglomerular infiltration

glomerulonephritis ( J:45448 )

• focal

homeostasis/metabolism

increased blood urea nitrogen level ( J:45448 )

• significantly elevated

increased urine protein level ( J:45448 )

• compared to age-matched B10.A mice

renal/urinary system

increased urine protein level ( J:45448 )

• compared to age-matched B10.A mice

kidney inflammation ( J:45448 )

• periglomerular infiltration

abnormal kidney morphology ( J:45448 )

abnormal renal glomerulus morphology ( J:45448 )

• glomerular hypercellularity

glomerulonephritis ( J:45448 )

• focal

hematopoietic system

increased double-negative T cell number ( J:26250 )

• develop massive lymphadenopathy due to alpha beta DN T cell accumulation

increased gamma-delta T cell number ( J:26250 )