Phenotypes Associated with This Genotype

Genotype
MGI:4944220

• Allelic Composition: Fas^lpr/Fas^lpr; Tcra^tm1Mjo/Tcra^tm1Mjo
• Genetic Background: involves: 129P2/OlaHsd * MRL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:26250 )

N • unlike in mutant mice wild-type for Tcra, massive lymphadenopathy is not seen at 16 weeks of age

increased T cell number ( J:26250 )

• 6 fold increase in TCRB+ cells compared to mutant mice wild-type for Fas

• within the TCRB+ cell population the proportion of DN B220+ cells is increased compared mutant mice wild-type for Fas

increased gamma-delta T cell number ( J:26250 )

• 15 fold expansion at 16 weeks of age compared to mutant mice wild-type for Fas

• the majority of these cells express B220 and DN as a result of preferential expansion (300 fold) of this population of cells

increased gamma-delta intraepithelial T cell number ( J:26250 )

• increase in the proportion of T cells in the peripheral lymph nodes expressing the gamma delta variable regions typical of intestinal intraepithelial T cell compared to mutant mice wild-type for Fas

kidney inflammation ( J:45448 )

• periglomerular infiltration and perivasculitis

renal/urinary system

increased urine protein level ( J:45448 )

• compared to age-matched B10.A mice

kidney inflammation ( J:45448 )

• periglomerular infiltration and perivasculitis

abnormal kidney morphology ( J:45448 )

• develop glomerular, interstitial and sometimes perivascular lesions

• lesion development is reduced compared mutant mice wild-type for Tcra

abnormal renal glomerulus morphology ( J:45448 )

• focal glomerular hypercellularity

homeostasis/metabolism

increased blood urea nitrogen level ( J:45448 )

• significantly elevated

increased urine protein level ( J:45448 )

• compared to age-matched B10.A mice

hematopoietic system

increased T cell number ( J:26250 )

• 6 fold increase in TCRB+ cells compared to mutant mice wild-type for Fas

• within the TCRB+ cell population the proportion of DN B220+ cells is increased compared mutant mice wild-type for Fas

increased gamma-delta T cell number ( J:26250 )

• 15 fold expansion at 16 weeks of age compared to mutant mice wild-type for Fas

• the majority of these cells express B220 and DN as a result of preferential expansion (300 fold) of this population of cells

increased gamma-delta intraepithelial T cell number ( J:26250 )

• increase in the proportion of T cells in the peripheral lymph nodes expressing the gamma delta variable regions typical of intestinal intraepithelial T cell compared to mutant mice wild-type for Fas