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Phenotypes Associated with This Genotype
Genotype
MGI:4943707
Allelic
Composition		 Il10tm1Cgn/Il10tm1Cgn
Il27ratm1Mak/Il27ratm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (43 available)
Il27ratm1Mak mutation (1 available); any Il27ra mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:136179 )
• compared with Il10tm1Cgn homozygotes

immune system
decreased susceptibility to induced colitis ( J:136179 )
• helminth-induced colitis compared with similarly treated Il10tm1Cgn homozygotes
colitis ( J:136179 )
• delayed and milder onset compared with Il10tm1Cgn homozygotes
abnormal T-helper 1 physiology ( J:136179 )
• mice exhibit lower Th1 response compared with Il10tm1Cgn homozygotes
• helminth-infected mice exhibit a decrease in Th1 response and an increase in Th2 response compared with similarly treated Il10tm1Cgn homozygotes
abnormal T-helper 2 physiology ( J:136179 )
• helminth-infected mice exhibit a decrease in Th1 response and an increase in Th2 response compared with similarly treated Il10tm1Cgn homozygotes
decreased interferon-gamma secretion ( J:136179 )
• in stimulated lymphocytes
• in mesenteric lymph node cells from helminth-infected mice compared with similarly treated Il10tm1Cgn homozygotes
increased interleukin-13 secretion ( J:136179 )
• in mesenteric lymph node cells from helminth-infected mice compared with similarly treated Il10tm1Cgn homozygotes

digestive/alimentary system
decreased susceptibility to induced colitis ( J:136179 )
• helminth-induced colitis compared with similarly treated Il10tm1Cgn homozygotes
colitis ( J:136179 )
• delayed and milder onset compared with Il10tm1Cgn homozygotes

hematopoietic system
abnormal T-helper 1 physiology ( J:136179 )
• mice exhibit lower Th1 response compared with Il10tm1Cgn homozygotes
• helminth-infected mice exhibit a decrease in Th1 response and an increase in Th2 response compared with similarly treated Il10tm1Cgn homozygotes
abnormal T-helper 2 physiology ( J:136179 )
• helminth-infected mice exhibit a decrease in Th1 response and an increase in Th2 response compared with similarly treated Il10tm1Cgn homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory