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Phenotypes Associated with This Genotype
Genotype
MGI:4943704
Allelic
Composition
Faslpr/Faslpr
Il27ratm1Mak/Il27ratm1Mak
Genetic
Background
MRL.Cg-Il27ratm1Mak Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (76 available)
Il27ratm1Mak mutation (1 available); any Il27ra mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 10% of mice die by week 24 compared with 50% of Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice

immune system
N
• mice exhibit unaltered lymphocyte compartment compared with Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• mice exhibit increased IgG1 depositions in the kidneys compared with Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• IgG1 serum levels are increased compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• mice exhibit reduced IgG2a renal deposits and serum levels compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• Th2-type immune response is favored compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• 10-fold in stimulated CD4+ T cells compared with similarly treated Faslpr/Faslpr Il27ratm1Mak/Il27ra+ cells
• mice exhibit improved survival, creatinine serum level, blood urea nitrogen serum level, and renal injury compared with Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• mice develop membranous glomerulonephritis

renal/urinary system
• mice develop membranous glomerulonephritis

homeostasis/metabolism
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice

hematopoietic system
• compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• mice exhibit increased IgG1 depositions in the kidneys compared with Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• IgG1 serum levels are increased compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• mice exhibit reduced IgG2a renal deposits and serum levels compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice
• Th2-type immune response is favored compared to in Faslpr/Faslpr Il27ratm1Mak/Il27ra+ mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
membranous glomerulonephritis DOID:10976 J:122148


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory