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Phenotypes Associated with This Genotype
Genotype
MGI:4943268
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Ptentm1Hwu/Ptentm1Hwu
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (51 available)
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
increased urinary bladder carcinoma incidence ( J:164579 )
• mice develop urothelial bladder tumors that progress to papillary carcinoma

renal/urinary system
increased urinary bladder carcinoma incidence ( J:164579 )
• mice develop urothelial bladder tumors that progress to papillary carcinoma

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory