Mouse Genome Informatics
cn
    Tg(Kit*D814V)1Roer/0
Tg(Mx1-cre)1Cgn/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• some mice, regardless of pIpC treatment, die or are euthanized due to severe disease between 15 and 35 weeks of age

digestive/alimentary system
• numerous neutrophilic crypt abscesses are detected in several mice with intestinal inflammation
• inflammation results in extensive destruction of the mucosa with crypts separated from each other and from the lamina muscularis propria by the infiltrating cells
• outside of inflammatory lesions the colonic mucosa appears normal with the exception of an increase in mast cell numbers
• in mice with intestinal inflammation
• in mice with intestinal inflammation
• diarrhea with bloody feces is seen in mice with intestinal inflammation
• in all mice, regardless of pIpC treatment
• severity of inflammation varies and severe inflammation is more common in older mice
• inflammatory changes affect sharply demarcated patches of the mucosa and in most mice occur in long stretches of the mucosa
• most lesions are found in the cecum and ascending colon
• lesions are characterized by a massive infiltration of T cells, B cells, macrophages, and neutrophils with high numbers of mast cells found in the crypt epithelium surrounding the lesion
• the surface epithelium shows erosions in several mice
• in a few mice, regardless of pIpC treatment

hematopoietic system
• most of the mast cells in pIpC treated mice with mastocytosis are round with some degree of hypergranulation and only few spindle shaped cells are seen
• mice treated with 3 injections of pIpC every second day at 4 to 10 weeks of age develop diffuse mastocytosis by 13 - 38 weeks of age
• pIpC treated mice display a variable increase in cutaneous mast cell numbers
• in some pIpC treated mice accumulations of mast cells are seen in the lymph nodes and/or spleen
• mice not treated with pIpC develop phenotypes similar to those in pIpC injected mice
• in mice with leukemia
• bone marrow cells are unable to engraft in nonirradiated recipient mice

tumorigenesis
• some pIpC treated mice develop large numbers of dermal mast cell tumors of variable size
• in a few mice these tumors are macroscopically visible
• mice not treated with pIpC develop phenotypes similar to those in pIpC injected mice
• some mice, regardless of pIpC treatment, develop a condition resembling B-lymphoblastic leukemia

growth/size/body
• in mice with intestinal inflammation

integument
• some pIpC treated mice develop large numbers of dermal mast cell tumors of variable size
• in a few mice these tumors are macroscopically visible
• mice not treated with pIpC develop phenotypes similar to those in pIpC injected mice

immune system
• in all mice, regardless of pIpC treatment
• severity of inflammation varies and severe inflammation is more common in older mice
• inflammatory changes affect sharply demarcated patches of the mucosa and in most mice occur in long stretches of the mucosa
• most lesions are found in the cecum and ascending colon
• lesions are characterized by a massive infiltration of T cells, B cells, macrophages, and neutrophils with high numbers of mast cells found in the crypt epithelium surrounding the lesion
• the surface epithelium shows erosions in several mice
• in a few mice, regardless of pIpC treatment
• most of the mast cells in pIpC treated mice with mastocytosis are round with some degree of hypergranulation and only few spindle shaped cells are seen
• mice treated with 3 injections of pIpC every second day at 4 to 10 weeks of age develop diffuse mastocytosis by 13 - 38 weeks of age
• pIpC treated mice display a variable increase in cutaneous mast cell numbers
• in some pIpC treated mice accumulations of mast cells are seen in the lymph nodes and/or spleen
• mice not treated with pIpC develop phenotypes similar to those in pIpC injected mice
• in mice with leukemia

endocrine/exocrine glands
• numerous neutrophilic crypt abscesses are detected in several mice with intestinal inflammation

Mouse Models of Human Disease
OMIM IDRef(s)
Mast Cell Disease 154800 J:169611