Phenotypes Associated with This Genotype

Genotype
MGI:4941337

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:98936 , J:214846 , J:276349 )

• PanIN-1 and PanIN-2, but not PanIN-3 or pancreatic ductal adenocarcinoma, are seen at 22 weeks after birth (J:214846)

• mice develop intraepithelial neoplasia (PanIN) by 8 weeks of age (J:276349)

• mice show accelerated PanIN development when treated with cerulein to induce acute pancreatitis (J:276349)

digestive/alimentary system

abnormal pancreatic duct morphology ( J:214846 )

• mice develop a varying number of ductal cell proliferation foci in the pancreas from 9 weeks after birth

endocrine/exocrine glands

abnormal pancreatic duct morphology ( J:214846 )

• mice develop a varying number of ductal cell proliferation foci in the pancreas from 9 weeks after birth

increased pancreatic intraepithelial neoplasia incidence ( J:98936 , J:214846 , J:276349 )

• PanIN-1 and PanIN-2, but not PanIN-3 or pancreatic ductal adenocarcinoma, are seen at 22 weeks after birth (J:214846)

• mice develop intraepithelial neoplasia (PanIN) by 8 weeks of age (J:276349)

• mice show accelerated PanIN development when treated with cerulein to induce acute pancreatitis (J:276349)