Phenotypes Associated with This Genotype

Genotype
MGI:4940115

• Allelic Composition: Ctla4^tm1All/Ctla4^tm1All; Rag1^tm1Mom/Rag1^tm1Mom; Tg(TcrAND)53Hed/0
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:119845 )

• nearly all CD4+ T cells in aged mice exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice

• however, lymph node T cells maintain a naive phenotype in young mice

increased T cell proliferation ( J:119845 )

• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1^tm1Mom/Rag1^tm1Mom Tg(TcrAND)53Hed mice

increased interleukin-4 secretion ( J:119845 )

• in response to primary and secondary pigeon cytochrome c stimulation, the frequency of IL4-secreting T cells is increased compared to in Rag1^tm1Mom/Rag1^tm1Mom Tg(TcrAND)53Hed mice

hematopoietic system

abnormal T cell activation ( J:119845 )

• nearly all CD4+ T cells in aged mice exhibit an activated phenotype unlike in Tg(TcrAND)53Hed mice

• however, lymph node T cells maintain a naive phenotype in young mice

increased T cell proliferation ( J:119845 )

• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1^tm1Mom/Rag1^tm1Mom Tg(TcrAND)53Hed mice

cellular

increased T cell proliferation ( J:119845 )

• CD4+ T cells exhibit increased primary and secondary antigen-specific proliferative responses compared to in Rag1^tm1Mom/Rag1^tm1Mom Tg(TcrAND)53Hed mice