Phenotypes Associated with This Genotype

Genotype
MGI:4940108

• Allelic Composition: Ctla4^tm1All/Ctla4^tm1All; Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:109887 )

N • mice survive beyond 3 to 4 weeks of age unlike Ctla4^tm1All homozygotes

immune system

insulitis ( J:109887 )

• splenocytes transferred into Tcra^tm1Mjo/Tcra^tm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4^tm1All/Ctla4⁺ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used

enlarged spleen ( J:109887 )

abnormal splenocyte physiology ( J:109887 )

• splenocytes transferred into Tcra^tm1Mjo/Tcra^tm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4^tm1All/Ctla4⁺ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used

increased acute inflammation ( J:109887 )

• at 6 weeks, mice exhibit infiltration in the pancreas and spleen unlike in wild-type mice

• however, infiltration is not as severe or extensive as in Ctla4^tm1All homozygotes

hematopoietic system

enlarged spleen ( J:109887 )

abnormal splenocyte physiology ( J:109887 )

• splenocytes transferred into Tcra^tm1Mjo/Tcra^tm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4^tm1All/Ctla4⁺ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used

endocrine/exocrine glands

insulitis ( J:109887 )

• splenocytes transferred into Tcra^tm1Mjo/Tcra^tm1Mjo Tg(TcraBDC2.5,TcrbBDC2.5)1Doi induce diabetes at a higher rate than when Ctla4^tm1All/Ctla4⁺ Tg(TcraBDC2.5,TcrbBDC2.5)1Doi splenocytes are used

growth/size/body

enlarged spleen ( J:109887 )