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Phenotypes Associated with This Genotype
Genotype
MGI:4940106
Allelic
Composition		 Brca2tm1Cam/Brca2tm1Brn
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Brn mutation (3 available); any Brca2 mutation (131 available)
Brca2tm1Cam mutation (0 available); any Brca2 mutation (131 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
exocrine pancreatic insufficiency ( J:166678 )
• small fraction of mutants develop pancreatic insufficiency

endocrine/exocrine glands
exocrine pancreatic insufficiency ( J:166678 )
• small fraction of mutants develop pancreatic insufficiency

mortality/aging
premature death ( J:166678 )
• premature death in the small fraction of mutants with pancreatic insufficiency

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory