Phenotypes Associated with This Genotype

Genotype
MGI:4939594

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Irf8^tm1.1Hm/Irf8^tm1.1Hm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:168923 )

N • spleen and lymph node sizes are normal

N • mice exhibit normal T-dependent and T-independent antibody responses

decreased follicular B cell number ( J:168923 )

• the proportion of AA4-B220+IgM^low CD19+ follicular B cells is decreased compared to in control mice

increased B cell number ( J:168923 )

• the frequency of CD19+B220+ B cells is increased compared to in control mice

• the number of total peritoneal B cells is increased compared to in control mice

increased transitional stage B cell number ( J:168923 )

• the frequency of B220+AA4+ transitional B cells is increased compared to in control mice

• the absolute number of transitional B cells is increased compared to in control mice

increased B-2 B cell number ( J:168923 )

• in the peritoneum

increased follicular B cell number ( J:168923 )

• the absolute number of follicular B cells is increased compared to in control mice

abnormal spleen marginal zone morphology ( J:168923 )

• mice exhibit enlarged marginal zones surrounding white pulp follicles compared with control mice

increased marginal zone B cell number ( J:168923 )

• the frequency of AA4-B220+IgM^hi CD19+ marginal zone B cells is increased compared to in control mice

• the absolute number of marginal zone B cells is increased compared to in control mice

hematopoietic system

decreased follicular B cell number ( J:168923 )

• the proportion of AA4-B220+IgM^low CD19+ follicular B cells is decreased compared to in control mice

increased B cell number ( J:168923 )

• the frequency of CD19+B220+ B cells is increased compared to in control mice

• the number of total peritoneal B cells is increased compared to in control mice

increased transitional stage B cell number ( J:168923 )

• the frequency of B220+AA4+ transitional B cells is increased compared to in control mice

• the absolute number of transitional B cells is increased compared to in control mice

increased B-2 B cell number ( J:168923 )

• in the peritoneum

increased follicular B cell number ( J:168923 )

• the absolute number of follicular B cells is increased compared to in control mice

abnormal spleen marginal zone morphology ( J:168923 )

• mice exhibit enlarged marginal zones surrounding white pulp follicles compared with control mice

increased marginal zone B cell number ( J:168923 )

• the frequency of AA4-B220+IgM^hi CD19+ marginal zone B cells is increased compared to in control mice

• the absolute number of marginal zone B cells is increased compared to in control mice