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Phenotypes Associated with This Genotype
Genotype
MGI:4879095
Allelic
Composition
Slc17a6tm1.1Thna/Slc17a6tm1.1Thna
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Slc6a3tm1(cre)Xz/Slc6a3+
Genetic
Background
involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1062 available)
Slc17a6tm1.1Thna mutation (0 available); any Slc17a6 mutation (60 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• only a minority of dopaminergic projections remain intake
• YFP+ dopamine neurons fail to exhibit glutamatergic excitatory postsynaptic currents (EPSCs) unlike control cells
• at P9 to P10, mice exhibit a reduction in glutamatergic with fewer neurons responding to ventral tegmental area stimulation compared with similarly treated control cells

behavior/neurological
• cocaine-treated mice exhibit less locomotor activity compared with control mice
• however, cocaine-treated mice exhibit conditioned place preference

homeostasis/metabolism
• the ventral striatum exhibit reduced dopamine and evoked dopamine release compared to in control mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory