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Phenotypes Associated with This Genotype
Genotype
MGI:4878990
Allelic
Composition		 Cxcr4tm2Yzo/Cxcr4tm3.1Yzo
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Cxcr4tm2Yzo mutation (1 available); any Cxcr4 mutation (50 available)
Cxcr4tm3.1Yzo mutation (0 available); any Cxcr4 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:167314 )
• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes

immune system
abnormal B cell differentiation ( J:167314 )
• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory