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Phenotypes Associated with This Genotype
Genotype
MGI:4868585
Allelic
Composition		 Gfi1tm1Wep/Gfi1tm1Wep
Gfi1btm2Tmo/Gfi1btm2Tmo
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1btm2Tmo mutation (0 available); any Gfi1b mutation (21 available)
Gfi1tm1Wep mutation (0 available); any Gfi1 mutation (34 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematopoietic stem cell number ( J:167416 )
• numbers drastically reduced 15 days after the first pIpC injection to induce cre expression
• numbers restored by 40 days
• Gfi1b excision is incomplete

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory