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Phenotypes Associated with This Genotype
Genotype
MGI:4868118
Allelic
Composition
Mybboo/Mybboo
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybboo mutation (0 available); any Myb mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• expanded numbers of primitive red blood cells in the blood at E14.5 (J:167270)
• expanded numbers of primitive red blood cells in the blood at E14.5 (J:167270)
• at 8 weeks of age (J:167270)
• at 8 weeks of age (J:167270)
• increased nuclear ploidy (J:167270)
• increased nuclear ploidy (J:167270)
• 8 fold increase in adult bone marrow (J:167270)
• 20 fold increase in the adult spleen (J:167270)
• 8 fold increase in adult bone marrow (J:167270)
• 20 fold increase in the adult spleen (J:167270)
• 3 fold increase at E14.5 (J:167270)
• 3 fold increase at E14.5 (J:167270)
• reduced numbers of definitive red blood cells in the blood at E14.5 (J:167270)
• reduced numbers of definitive red blood cells in the blood at E14.5 (J:167270)
• at E14.5 (J:167270)
• at E14.5 (J:167270)
• polychromasia (J:167270)
• polychromasia (J:167270)
• 5-10 fold increase in circulating platelets at E14.5 (J:167270)
• marked increase in platelets at 8 weeks of age (J:167270)
• 5-10 fold increase in circulating platelets at E14.5 (J:167270)
• marked increase in platelets at 8 weeks of age (J:167270)
• increased reticulocyte numbers at 8 weeks of age (J:167270)
• increased reticulocyte numbers at 8 weeks of age (J:167270)
• 4 fold increase in long term hematopoietic stem cells at E14.5 (J:167270)
• 3 fold increase in multipotent progenitor cells at E14.5 (J:167270)
• 3 fold decrease in granulocyte/macrophage progenitor cells at E14.5 (J:167270)
• 2 fold decrease in megakaryocyte/erythrocyte progenitor cells at E14.5 (J:167270)
• 4 fold increase in long term hematopoietic stem cells at E14.5 (J:167270)
• 3 fold increase in multipotent progenitor cells at E14.5 (J:167270)
• 3 fold decrease in granulocyte/macrophage progenitor cells at E14.5 (J:167270)
• 2 fold decrease in megakaryocyte/erythrocyte progenitor cells at E14.5 (J:167270)
• reduced B cell lymphopoiesis (J:167270)
• reduced B cell lymphopoiesis (J:167270)
• neutropenia at 8 weeks of age (J:167270)
• neutropenia at 8 weeks of age (J:167270)
• disorganized splenic architecture (J:167270)
• disorganized splenic architecture (J:167270)
• expanded red pulp (J:167270)
• expanded red pulp (J:167270)
• moderate splenomegaly in adults (J:167270)
• moderate splenomegaly in adults (J:167270)

embryogenesis
• expanded numbers of primitive red blood cells in the blood at E14.5 (J:167270)
• expanded numbers of primitive red blood cells in the blood at E14.5 (J:167270)

immune system
• reduced B cell lymphopoiesis (J:167270)
• reduced B cell lymphopoiesis (J:167270)
• neutropenia at 8 weeks of age (J:167270)
• neutropenia at 8 weeks of age (J:167270)
• disorganized splenic architecture (J:167270)
• disorganized splenic architecture (J:167270)
• expanded red pulp (J:167270)
• expanded red pulp (J:167270)
• moderate splenomegaly in adults (J:167270)
• moderate splenomegaly in adults (J:167270)

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelofibrosis 254450 J:167270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory