Phenotypes Associated with This Genotype

Genotype
MGI:4868118

• Allelic Composition: Myb^boo/Myb^boo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal embryonic erythropoiesis ( J:167270 )

• expanded numbers of primitive red blood cells in the blood at E14.5

abnormal definitive hematopoiesis ( J:167270 )

anemia ( J:167270 )

• at 8 weeks of age

abnormal megakaryocyte morphology ( J:167270 )

• increased nuclear ploidy

increased megakaryocyte cell number ( J:167270 )

• 8 fold increase in adult bone marrow

• 20 fold increase in the adult spleen

abnormal common lymphocyte progenitor cell morphology ( J:167270 )

• 3 fold increase at E14.5

abnormal erythrocyte morphology ( J:167270 )

abnormal erythropoiesis ( J:167270 )

• reduced numbers of definitive red blood cells in the blood at E14.5

increased nucleated erythrocyte cell number ( J:167270 )

• at E14.5

increased number of Howell-Jolly bodies ( J:167270 )

polychromatophilia ( J:167270 )

• polychromasia

thrombocytosis ( J:167270 )

• 5-10 fold increase in circulating platelets at E14.5

• marked increase in platelets at 8 weeks of age

reticulocytosis ( J:167270 )

• increased reticulocyte numbers at 8 weeks of age

increased hematopoietic stem cell number ( J:167270 )

• 4 fold increase in long term hematopoietic stem cells at E14.5

• 3 fold increase in multipotent progenitor cells at E14.5

• 3 fold decrease in granulocyte/macrophage progenitor cells at E14.5

• 2 fold decrease in megakaryocyte/erythrocyte progenitor cells at E14.5

abnormal leukocyte morphology ( J:167270 )

abnormal B cell differentiation ( J:167270 )

• reduced B cell lymphopoiesis

decreased neutrophil cell number ( J:167270 )

• neutropenia at 8 weeks of age

abnormal spleen morphology ( J:167270 )

• disorganized splenic architecture

enlarged spleen ( J:167270 )

• moderate splenomegaly in adults

increased spleen red pulp amount ( J:167270 )

• expanded red pulp

decreased spleen white pulp amount ( J:167270 )

embryo

abnormal embryonic erythropoiesis ( J:167270 )

• expanded numbers of primitive red blood cells in the blood at E14.5

immune system

abnormal leukocyte morphology ( J:167270 )

abnormal B cell differentiation ( J:167270 )

• reduced B cell lymphopoiesis

decreased neutrophil cell number ( J:167270 )

• neutropenia at 8 weeks of age

abnormal spleen morphology ( J:167270 )

• disorganized splenic architecture

enlarged spleen ( J:167270 )

• moderate splenomegaly in adults

increased spleen red pulp amount ( J:167270 )

• expanded red pulp

decreased spleen white pulp amount ( J:167270 )

growth/size/body

enlarged spleen ( J:167270 )

• moderate splenomegaly in adults

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
essential thrombocythemia		DOID:2224	OMIM:187950 OMIM:601977 OMIM:614521	J:167270
myelofibrosis		DOID:4971	OMIM:254450	J:167270