About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4868118
Allelic
Composition
Mybboo/Mybboo
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybboo mutation (0 available); any Myb mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• expanded numbers of primitive red blood cells in the blood at E14.5
• at 8 weeks of age
• increased nuclear ploidy
• 8 fold increase in adult bone marrow
• 20 fold increase in the adult spleen
• reduced numbers of definitive red blood cells in the blood at E14.5
• polychromasia
• 5-10 fold increase in circulating platelets at E14.5
• marked increase in platelets at 8 weeks of age
• increased reticulocyte numbers at 8 weeks of age
• 4 fold increase in long term hematopoietic stem cells at E14.5
• 3 fold increase in multipotent progenitor cells at E14.5
• 3 fold decrease in granulocyte/macrophage progenitor cells at E14.5
• 2 fold decrease in megakaryocyte/erythrocyte progenitor cells at E14.5
• reduced B cell lymphopoiesis
• neutropenia at 8 weeks of age
• disorganized splenic architecture
• expanded red pulp
• moderate splenomegaly in adults

embryo
• expanded numbers of primitive red blood cells in the blood at E14.5

immune system
• reduced B cell lymphopoiesis
• neutropenia at 8 weeks of age
• disorganized splenic architecture
• expanded red pulp
• moderate splenomegaly in adults

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelofibrosis 254450 J:167270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory