Mouse Genome Informatics
hm
    Mybboo/Mybboo
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• expanded numbers of primitive red blood cells in the blood at E14.5
• reduced numbers of definitive red blood cells in the blood at E14.5
• at 8 weeks of age
• polychromasia
• increased reticulocyte numbers at 8 weeks of age
• neutropenia at 8 weeks of age
• reduced B cell lymphopoiesis
• increased nuclear ploidy
• 5-10 fold increase in circulating platelets at E14.5
• marked increase in platelets at 8 weeks of age
• 8 fold increase in adult bone marrow
• 20 fold increase in the adult spleen
• 4 fold increase in long term hematopoietic stem cells at E14.5
• 3 fold increase in multipotent progenitor cells at E14.5
• 3 fold decrease in granulocyte/macrophage progenitor cells at E14.5
• 2 fold decrease in megakaryocyte/erythrocyte progenitor cells at E14.5
• disorganized splenic architecture
• expanded red pulp
• moderate splenomegaly in adults

embryogenesis
• expanded numbers of primitive red blood cells in the blood at E14.5

immune system
• neutropenia at 8 weeks of age
• reduced B cell lymphopoiesis
• disorganized splenic architecture
• expanded red pulp
• moderate splenomegaly in adults

Mouse Models of Human Disease
OMIM IDRef(s)
Myelofibrosis 254450 J:167270