Phenotypes Associated with This Genotype

Genotype
MGI:4843925

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Smo/EYFP)Amc}/Gt(ROSA)26Sor⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:135134 )

• half of mice die at E11.5

embryo

increased cardiac neural crest cell number ( J:135134 )

• the number of cardiac neural crest cells is increased in the cardiac jelly compared to in wild-type mice

cardiovascular system

increased cardiac neural crest cell number ( J:135134 )

• the number of cardiac neural crest cells is increased in the cardiac jelly compared to in wild-type mice

abnormal cardiac outflow tract development ( J:135134 )

• at E11.5, surviving mice exhibit a lack of cushions in the distal outflow tract while more proximal outflow tract cushions are closer to each other unlike in wild-type mice

persistent truncus arteriosus ( J:135134 )

• at E15.5

nervous system

increased cardiac neural crest cell number ( J:135134 )

• the number of cardiac neural crest cells is increased in the cardiac jelly compared to in wild-type mice