About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4839763
Allelic
Composition		 Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago2tm1.1Tara mutation (1 available); any Ago2 mutation (56 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
anemia ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
abnormal erythrocyte morphology ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells, red blood cells contain Heinz bodies and hemoglobin precipitates unlike in cells from mice reconstituted with untreated bone marrow
abnormal erythropoiesis ( J:165967 )
• erythroid precursor maturation is severely impaired with erythroid hyperplasia in bone marrow and spleen in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells compared to when untreated bone marrow is used
decreased erythrocyte cell number ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
decreased hematocrit ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
decreased hemoglobin content ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
decreased mean corpuscular hemoglobin ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
decreased mean corpuscular volume ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
increased red blood cell distribution width ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
reticulocytosis ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
abnormal erythrocyte physiology ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells

immune system
enlarged spleen ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells

growth/size/body
enlarged spleen ( J:165967 )
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory