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Phenotypes Associated with This Genotype
Genotype
MGI:4838437
Allelic
Composition		 Elmo1tm1.1Ravi/Elmo1tm1.1Ravi
Tg(Amh-cre)8815Reb/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1tm1.1Ravi mutation (0 available); any Elmo1 mutation (58 available)
Tg(Amh-cre)8815Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:164662 )
• apoptosis of spermatogenesis in middle and late stages is increased compared to in wild-type mice
abnormal seminiferous tubule morphology ( J:164662 )
• mice contain an increased number of uncleared apoptotic nuclei compared to in wild-type mice

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:164662 )
• mice contain an increased number of uncleared apoptotic nuclei compared to in wild-type mice

cellular
increased male germ cell apoptosis ( J:164662 )
• apoptosis of spermatogenesis in middle and late stages is increased compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory