Phenotypes for Pten Tg(Pdx1-cre)89.1Dam Trp53 MGI:4836239 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Tg(Pdx1-cre)89.1Dam/0 Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (236 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic acinar cell carcinoma incidence ( J:102226 )

• 1 of 5 mutants develop a small acinar carcinoma

increased pancreatic ductal adenocarcinoma incidence ( J:102226 )

• 2 of 5 mutants develop papillary adenocarcionomas at 4 and 6 months of age

endocrine/exocrine glands

increased pancreatic acinar cell carcinoma incidence ( J:102226 )

• 1 of 5 mutants develop a small acinar carcinoma

increased pancreatic ductal adenocarcinoma incidence ( J:102226 )

• 2 of 5 mutants develop papillary adenocarcionomas at 4 and 6 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24