Phenotypes Associated with This Genotype

Genotype
MGI:4835498

• Allelic Composition: Mdm2^tm3.1Glo/Mdm2^tm3.1Glo; Trp53^tm3.1Glo/Trp53⁺
• Genetic Background: B6.129S-Mdm2^tm3.1Glo Trp53^tm3.1Glo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:164201 )

• overall survival is reduced relative to mice homozygous for Mdm2^tm4.1Glo and heterozygous for Trp53 ^tm3.1Glo

cellular

decreased cellular sensitivity to ionizing radiation induced cell death ( J:164201 )

• in the thymus following a low dose of IR radiation compared to mice homozygous for Mdm2^tm4.1Glo and heterozygous for Trp53^tm3.1Glo

neoplasm

increased tumor incidence ( J:164201 )

• accelerated tumor onset relative to mice homozygous for Mdm2^tm4.1Glo and heterozygous for Trp53 ^tm3.1Glo

• the tumor spectrum is also altered relative to mice homozygous for Mdm2^tm4.1Glo and heterozygous for Trp53 ^tm3.1Glo

• mice develop multiple primary tumors

increased liver adenoma incidence ( J:164201 )

• in 1 mouse

increased lung adenoma incidence ( J:164201 )

• in 1 mouse

increased lipoma incidence ( J:164201 )

increased lymphoma incidence ( J:164201 )

increased histiocytic sarcoma incidence ( J:164201 )

increased carcinoma incidence ( J:164201 )

• salivary carcinoma in 1 mouse

• undefined carcinomas are also reported

increased adenocarcinoma incidence ( J:164201 )

increased mammary adenocarcinoma incidence ( J:164201 )

increased liver adenocarcinoma incidence ( J:164201 )

• in 1 mouse

increased squamous cell carcinoma incidence ( J:164201 )

increased sarcoma incidence ( J:164201 )

• soft tissue sarcoma

• chondrosarcoma in 1 mouse

increased leiomyosarcoma incidence ( J:164201 )

• in 1 mouse

increased fibrosarcoma incidence ( J:164201 )

increased hemangiosarcoma incidence ( J:164201 )

• ovarian

increased osteosarcoma incidence ( J:164201 )

increased papilloma incidence ( J:164201 )

• squamous cell papilloma in 1 mouse

muscle

increased leiomyosarcoma incidence ( J:164201 )

• in 1 mouse

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:164201 )

integument

increased mammary adenocarcinoma incidence ( J:164201 )

skeleton

increased osteosarcoma incidence ( J:164201 )

liver/biliary system

increased liver adenocarcinoma incidence ( J:164201 )

• in 1 mouse

increased liver adenoma incidence ( J:164201 )

• in 1 mouse

respiratory system

increased lung adenoma incidence ( J:164201 )

• in 1 mouse

homeostasis/metabolism

decreased cellular sensitivity to ionizing radiation induced cell death ( J:164201 )

• in the thymus following a low dose of IR radiation compared to mice homozygous for Mdm2^tm4.1Glo and heterozygous for Trp53^tm3.1Glo