Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Mdm2tm3.1Glo
Name:	transformed mouse 3T3 cell double minute 2; targeted mutation 3.1, Guillermina Lozano
MGI ID:	MGI:4835494
Synonyms:	Mdm2SNP309G
Gene:	Mdm2  Location: Chr10:117524780-117546663 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Alliance:	Mdm2tm3.1Glo page

Germline Transmission:	Earliest citation of germline transmission: J:164201
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: Intron 1 was replaced with the corresponding human intron 1 with a G in position 309. A floxed neo cassette was also inserted into intron 3 and then removed via Cre mediated recombination. RT-PCR analysis indicated higher levels of RNA expression in spleens and thymi from homozygous mice relative to wild-type mice. (J:164201)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Mdm2tm3.1Glo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:	54 strains or lines available

Original:	J:164201 Post SM, et al., A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell. 2010 Sep 14;18(3):220-30
All:	3 reference(s)