Mdm2^tm3.1Glo
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm3.1Glo
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 3.1, Guillermina Lozano
• MGI ID: MGI:4835494
• Synonyms: Mdm2^SNP309G
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm3.1Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164201
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Intron 1 was replaced with the corresponding human intron 1 with a G in position 309. A floxed neo cassette was also inserted into intron 3 and then removed via Cre mediated recombination. RT-PCR analysis indicated higher levels of RNA expression in spleens and thymi from homozygous mice relative to wild-type mice. (J:164201)

Tumor Data

List all tumor models in MMHCdb carrying Mdm2^tm3.1Glo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 51 strains or lines available

References

• Original: J:164201 Post SM, et al., A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell. 2010 Sep 14;18(3):220-30
• All: 3 reference(s)